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-Heinz Birnesser, Peter Klein, Michael Weiser
Relieving pain and reducing inflammation
are the cornerstones of pharmaceutical therapy for osteoarthritis of the knee. Depending on the patient’s
symptoms, treatment may be either systemic or topical and may include
peripherally active analgesics,
anti-inflammatories such as COX 1 or COX 2 inhibitors, topical steroids,
hyaluronic acid, and therapeutic injections
of local anesthetics.1 More and more physicians, however, are prescribing alternative therapeutic
In homeopathy, for example, potentized
extracts of Rhus toxicodendron, Solanum dulcamara, and Sanguinaria canadensis are used to relieve the
pain and inflammation of rheumatic conditions. These three ingredients
are combined with Arnica montana and sulfur in the homeopathic medication
Zeel® comp. N (tablets).
A previous controlled, double-blind
clinical study proved that the clinical efficacy of this combination medication
is equivalent to that of COX 1
inhibitors in treating mild to moderate osteoarthritis of the knee.2, 3 The
purpose of the present study is to
compare the efficacy of Zeel® comp.N
and COX 2 inhibitors.