Antimalarial potential of China 30 and Chelidonium 30 in animal model

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Homoeopathy is a therapeutic method based on the application of similia principle, utilizing ultra-low doses of medicinal substances made from natural products. The present study has been designed to evaluate the efficacy of Cinchona officinalis (Chin.) 30C and Chelidonium majus (Chel.) 30C in combination therapy against lethal murine malaria. Five groups having twelve BALB/c mice each were administered orally with 0.2 ml/mouse/day of different drugs, and their antimalarial potential was evaluated by Peter's 4-day test. The combination of Chin. 30 and Chel. 30 exhibited complete parasite clearance by the 28th day post-inoculation which was similar to the positive control [artesunate (4 mg/kg)+sulphadoxine-primethamine (1.2 mg/kg)] group. Both the groups exhibited enhanced mean survival time (MST) 28±0 days,whereas, the mice of infected control group survived up to 7.6±0.4 days only. The preventive and curative activities of the combination in comparison to the positive controls [pyrimethamine (1.2 mg/Kg) and chloroquine (20 mg/Kg), respectively] were also evaluated. The combination had a significant preventive activity (p<0 .0005="" 26.8="" 50="" 89.2="" a="" activity="" against="" also="" and="" anti-plasmodial="" berghei.="" chemo="" clearance="" combination="" complete="" curative="" days.="" drug="" drugs="" efficacy="" enhancing="" findings="" higher="" homoeopathic="" in="" it="" mice="" moderate="" mst="" of="" parasite="" plasmodium="" point="" pyrimethamine="" showed="" significant="" span="" standard="" suppression="" surviving="" than="" the="" these="" to="" up="" was="" which="" with="">
Reference: Rajan A, Bagai U., Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei., Journal of Complementary and Integrative Medicine, 2013 May 7;10(1):1-8.

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