Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model
- schwabe, Research news Aconitum napellus is a very frequently used homoeopathic medicine for many complaints associated with anxiety or fear. This study was conducted to scientifically assess the action of this drug in the treatment of generalized anxiety in an experimental model using rats. In this study, 48 adult (two to three months old) male Wistar rats (Rattus rattus) were randomly divided in six groups (n= 8/treatment) and given the following treatments by gastric tube along 10 days: 1) control (diazepam 1 mg/kg/day); 2) negative control (0.15 mL saline solution/day); 3) ACH6 (0.15 mL Acon (6cH/day); 4) ACH12 (0.15 mL Acon 12cH/day); 5) ACH30 (0.15 mL Acon 30cH/day); and 6) ALC30 (0.15 mL 30% cereal alcohol/day). Behavioral effects were blindly and randomly assessed in elevated plus maze (EPM) and open field test. The results showed that the drug in dilutions 12CH and 30CH exhibited possible anxiolytic effects on the central nervous system (CNS)...